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Animal model research has shown that the central features of tinnitus, the perception of sound without an acoustic correlate, include elevated spontaneous and stimulus-driven activity, enhanced burst-mode firing, decreased variance of inter-spike intervals, and distortion of tonotopic frequency representation. Less well documented are cell-specific correlates of tinnitus. Unipolar brush cell UBC alterations in animals with psychophysical evidence of tinnitus has recently been reported. UBCs are glutamatergic interneurons that appear to function as local-circuit signal amplifiers. In the present research, two indicators of UBC structure and function were examined: Doublecortin DCX and epidermal growth factor receptor substrate 8 Eps8. DCX is a protein that binds to microtubules where it can modify their assembly and growth.

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Gregg Popovich praises Tony Parker prior to his return to San Antonio for the first time since he signed with the Hornets as a free agent. Still hurt by his departure from San Antonio, Parker nonetheless wants to "focus on the great 17 years we had. Parker loves San Antonio -- misses "everything about it," he says -- and plans to live there once his sure-to-be Hall of Fame career comes to a close. At the same time, Parker laments that he didn't get the opportunity to show the Spurs he could still perform at a high level one season removed from the ruptured left quadriceps tendon many thought would end his career. Especially after he rushed back in days from what was initially diagnosed as a or month recovery to help a struggling San Antonio squad missing an injured Kawhi Leonard. Parker, 36, finds something invigorating about his new role with the Charlotte Hornets as a backup point guard and mentor.
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Patrick Mahomes picked up where he left off from his record-breaking debut as a starter, marching the Kansas City Chiefs downfield for a first-quarter touchdown in what became a preseason victory over the Cincinnati Bengals on Saturday night. Halftime: Kansas City leads Cincinnati in the preseason opener for both teams. The Bengals' backups have struggled to move the ball and the Chiefs' have racked up big offensive plays against Cincy's reserves. Cincinnati's offensive line struggled at times in the first half. Left guard John Jerry was whistled for two holding penalties and the backups gave up two sacks on the last drive of the half.
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We hypothesized that an active immunotherapy approach targeting flk1 may inhibit tumor angiogenesis and metastasis. To test this hypothesis, we first evaluated whether immune responses to flk1 could be elicited in mice by immunization with dendritic cells pulsed with a soluble flk1 protein DC-flk1. Tumor-induced angiogenesis was suppressed in immunized mice as measured in an alginate bead assay. Development of pulmonary metastases was strongly inhibited in DC-flk1—immunized mice challenged with B16 melanoma or Lewis lung carcinoma cells.
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